Specifically, it is not known if active metabolites are generated in humans. The metabolic disposition of trimethobenzamide in humans is not known. Between 30 – 50% of a single dose in humans is excreted unchanged in the urine within 48 – 72 hours. The mean elimination half-life of trimethobenzamide is 7 to 9 hours. The relative bioavailability of the capsule formulation compared to the solution is 100%. A single dose of Tigan 300 mg oral capsule provided a plasma concentration profile of trimethobenzamide similar to Tigan 200 mg IM. Following administration of 200 mg (100 mg/mL) Tigan IM injection, the time to reach maximum plasma concentration (T max) was about half an hour, about 15 minutes longer for Tigan 300 mg oral capsule than an IM injection. The pharmacokinetics of trimethobenzamide have been studied in healthy adult subjects. In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.
The mechanism of action of Tigan ® as determined in animals is obscure, but may involve the chemoreceptor trigger zone (CTZ), an area in the medulla oblongata through which emetic impulses are conveyed to the vomiting center direct impulses to the vomiting center apparently are not similarly inhibited. Tigan Injection - Clinical Pharmacology Mechanism of Action Multi-Dose Vials: Each mL contains 100 mg trimethobenzamide hydrochloride compounded with 0.45% phenol as preservative, 0.5 mg sodium citrate and 0.2 mg citric acid as buffers and pH adjusted to approximately 5.0 with sodium hydroxide. Patients Should Follow The Advice Of The Doctor Regarding Its Use.Single Dose Vials: Each 2-mL single-dose vial contains 200 mg trimethobenzamide hydrochloride compounded with 1 mg sodium citrate and 0.4 mg citric acid as buffers and pH adjusted to approximately 5.0 with sodium hydroxide. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant.
Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. How Dicyclomine will impact during lactation(breastfeeding) ? Patients Should Follow The Advice Of The Doctor Regarding Its Use.
Studies In Animals Have Shown No Risk To The Fetus, However There Are No Sufficient Studies In Humans. How Dicyclomine will impact on Pregnancy ? Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.Ĭonstipation, Bloating, Stomach Pain, Dizziness, Drowsiness, Dry Mouth, Dry Eye, Blurred Vision, Urge To Vomit (nausea), Tingling, Confusion, Unusual Thoughts Or Behavior, Sleepiness, Weakness, Nervousness, And Difficulty Or Pain On Passing Urine. Antacids May Also Interfere With Action Of Dicyclomine. Inhibits Effects Of Glaucoma Therapy, May Increase Certain Actions Or Side Effects Of Anticholinergic Drugs (atropine, Glycopyrrolate, Scopolamine), Antiarrhythmic Agents (disopyramide, Quinidine), Antihistamines (chlorpheniramine, Levocetirizine), Antipsychotic Agents (phenothiazines), Certain Drugs Used To Treat Parkinson's Disease (benztropine, Trihexyphenidyl, Isocarboxazid, Linezolid, Methylene Blue, Moclobemide, Phenelzine, Procarbazine, Rasagiline, Selegiline, Tranylcypromine), Drugs For Sleep Or Anxiety (alprazolam, Diazepam, Zolpidem), Narcotic Analgesics (meperidine), Tricyclic Antidepressants (amitriptyline), Nitrates And Nitrites. To Treat Periodic Spasm And Pain In Abdomen, Stomach And Intestinal Cramps, Functional Bowel Or Irritable Bowel Syndrome And Urinary Incontinence.ĭicyclomine Acts By Relieving The Smooth Muscle Contraction Of The Gastrointestinal Tract Via Dual Action: (i) By A Specific Action (anticholinergic), Which Reduces Muscle Contractions And (ii) By A Direct Effect Upon Smooth Muscle Of The Stomach And Intestine (musculotropic) Leading To Muscle Relaxations, And Decrease In Contraction And Pain.
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